About NANO MRNA

NANO MRNA is evoluving a cycle of mRNA medicine IP generation-licensing as a platform company that connects drug discovery seeds with medical and drug development needs.

CEO Message

Happy New Year

I hope the New Year finds all of you in good health and happiness.

Last year, we pivoted to the new business model of mRNA drug discovery, and changed our company name accordingly, adopting NANO MRNA Co., Ltd.

On the R&D front, we are pursuing the partnering and enhancement of R&D talent that will drive mRNA drug discovery. Meanwhile our drug discovery activities have successfully launched and been in full operation, and in addition to our alliance with Kao, our newly established mRNA IPG Unit is already producing and starting projects based on new ideas. In 2024 as our IP generation model enters its second year, we will ensure that intellectual property (IP) rights are secured in connection with those efforts, while leveraging collaborations and other activities as multiplier to enhance new seeds. With the IP creation cycle leading to the ongoing creation of IPs going forward, we will step up to a new level, aiming to become a first-tier company in terms of mRNA drug creation capabilities.

Regarding the RUNX1 mRNA, we are making progress in consultations with regulatory authorities towards the start of investigator-initiated clinical trials, and in this process have rapidly gained a wealth of expertise that will benefit the future research and development of mRNA drugs. The investigator-initiated clinical trial of TUG1 ASO is also about to begin. TUG1 ASO has potential as a new therapeutics for intractable cancer, and we believe that this clinical trial steady progress will also make steady progress. We will pursue out-licensing activities in parallel with these efforts.

We truly appreciate your continued support for our activities.

Last but not least, I sincerely wish you all have a wonderful New Year.

Sincerely yours,

Shiro Akinaga,<br />
President & CEO<br />
Jan. 1, 2024

Shiro Akinaga,
President & CEO
Jan. 1, 2024

Corporate Profile

Corporate Nam NANO MRNA Co.,Ltd.
Location
Tokyo Office (Head office)

Atago Green Hills MORI Tower 26F
2-5-1 Atago, Minato-ku, Tokyo
TEL: +81 (0)3-6432-4791 FAX: +81 (0)3-6432-4794

Lab (iCONM laboratory)

Innovation Center of NanoMedicine(iCONM) 3-25-14 Tonomachi,
Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-0821, Japan
TEL: +81 (0)44-589-8832 FAX: +81 (0)44-589-8833

Establishment June 14, 1996
President and CEO Shiro Akinaga
Capital 119 million yen (As of March 31, 2023)
Number of employees & management 28 (As of March 31, 2023)
Scopes of Business R&D and production of pharmaceuticals using micellar nanoparticles technology.

Management

Shiro Akinaga, Ph.D.

President and CEO

Career Summary
Apr. 1981 Joined Kyowa Hakko Kogyo Co., Ltd. (currently Kyowa Kirin Co., Ltd.)
Apr. 1994 Senior Researcher at pharmaceutical research center of Kyowa Hakko
2001年04月 Therapeutic Area Manager of oncology group at Drug Discovery Research Division of Kyowa Hakko
Apr. 2006 Served as Director of International Development Department and Director of Clinical Development I Department, R&D Division of Kyowa Hakko
Oct. 2008 Director, Clinical Development I Department, Development Division of Kyowa Hakko Kirin Co., Ltd. (currently Kyowa Kirin Co., Ltd.)
Mar. 2011 Executive Officer (International Development) of Kyowa Hakko Kirin
Mar. 2013 Fellow of Kyowa Hakko Kirin
Mar. 2017 Director and CSO of AccuRna, Inc.
Nov. 2018 Chairman of the board, CEO of AccuRna, Inc.
Jun. 2020 Director of the Company
Sep. 2020 Managing Director of R&D Division & CSO of the Company
Sep. 2022 Representative Director and President of PrimRNA, Inc. (current)
Dec. 2022 President and CEO, Managing Director of R&D Division & CSO of the Company
Oct. 2023 President and CEO (current)

Atsushi Matsumura

Board of Director

Career Summary
Apr. 1986 Joined Nomura Securities, Co., Ltd
Jan. 2008 Representative Director of Quiet Partners Inc.
Sep. 2010 President of Whiz Partners Inc.
Mar. 2012 Director of the Company
Mar. 2017 Director of ALBERT Inc.
Dec. 2019 Chairman of the board of AXEL MARK INC.
Apr. 2020 Chairman of the board of Axcelead, Inc. (current)
May 2020 President and CEO of Whiz Partners Inc. (current)
Mar. 2021 Director of AXEL MARK INC. (current)
Jun. 2021 Director of the Company
Jan. 2023 Chairman and Director of the Company (current)

Koji Fujimoto

Managing Director of Corporate Division

Career Summary
Apr. 1996 Joined Nissan Construction Co., Ltd. (currently Rinkai Nissan Construction Co., Ltd.)
Nov. 2002 Joined the Company
Jul. 2005 Manager of General Affairs and HR Section, Administration Department of the Company
May 2015 Deputy Director of Administration Department of the Company
Apr. 2017 Director of General Affairs and HR Department of the Company
Dec. 2019 Managing Director of Corporate Division
Jun. 2020 Managing Director of Corporate Department of the Company (current)

Teruo Okano, Ph.D.

Board of Director

Career Summary
Jan. 1994 Professor at Institute of Biomedical Engineering, Tokyo Women’s Medical University
Affiliate Professor at Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah (U.S.) (current)
Jun. 1996 Director of the Company (current)
Apr. 2001 Director and Professor at Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University
May 2001 Director of CellSeed Inc.
Apr. 2014 Professor Emeritus (current) and Professor by Special Appointment at Tokyo Women’s Medical University
Sep. 2016 Director of Cell Sheet Tissue Engineering Center, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah (U.S.) (current)
Apr. 2020 Director of Institute of Advanced BioMedical Engineering and Science, Tokyo Women’s Medical University
Apr. 2022 Consultant by Special Appointment at the Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University (current)

Kazunori Kataoka, Ph.D.

Board of Director

Career Summary
Apr. 1979 Served as assistant, lecturer and Assistant Professor at Institute of Biomedical Engineering, Tokyo Women’s Medical University
Apr. 1989 Served as Assistant Professor and Professor at Faculty of Industrial Science and Technology, Tokyo University of Science
Apr. 1998 Professor at School of Engineering, the University of Tokyo
Jul. 2004 Professor at Graduate School of Medicine, the University of Tokyo (concurrent)
Jul. 2015 Director General of Innovation Center of NanoMedicine (current)
Apr. 2016 Professor by Special Appointment at the University of Tokyo
Jun. 2016 Professor Emeritus of the University of Tokyo (current)
Jul. 2016 Vice-Director General at Kawasaki Institute of Industry Promotion (current)
Jun. 2020 Director of Nissan Chemical Corporation (current)
Director of the Company (current)

Satoru Iino

Board of Director

Career Summary
Apr. 1989 Joined Hitachi, Ltd.
Mar. 2020 Joined CSK Venture Capital Co., Ltd.
Feb. 2004 Director of CSK Venture Capital
Sep. 2010 Executive Officer of Whiz Partners Inc.
Mar. 2012 Director of the Company
Apr. 2013 Managing Director of Investment Management Department of Whiz Partners Inc.
Jun. 2013 Director of Advanced Media, Inc.
Mar. 2015 Managing Director and CIO of Fund Business of Whiz Partners Inc.
Mar. 2017 Director of ALBERT Inc.
Dec. 2019 Director of AXEL MARK INC.
Director of CRI Middleware Co., Ltd. (current)
Apr. 2020 Director of the board of Axcelead, Inc. (current)
Feb. 2021 President and Co-CEO of ARCALIS, Inc.
Jun. 2021 Director of the Company (current)
Director, COO and Co-CIO of Whiz Partners Inc. (current)
Jul. 2022 Chairman of IPGaia, Inc. (current)
Apr. 2023 Chairman of AXEL MARK INC. (current)
May 2023 Chairman of ARCALIS, Inc. (current)

Yuki Hasegawa

Board of Director

Career Summary
Jan. 2007 Researcher at RIKEN Genome Sciences Research Complex
Apr. 2008 Postdoctoral Fellow at RIKEN Omics Science Center
Apr. 2010 Research Scientist at RIKEN Omics Science Center
Apr. 2013 Deputy Team Leader at RIKEN Center for Life Science Technologies
Sep. 2014 Researcher at Asahi Kasei Corp.
Jul. 2016 Associate Director of Whiz Partners Inc.
Apr. 2019 Director of Whiz Partners Inc.
May 2021 Head of Healthcare Investment at Whiz Partners Inc. (current)
Jun. 2021 Director of the Company (current)
Oct. 2021 Director of IPGaia, Inc. (current)

Tetsuhito Matsuyama

Auditors

Career Summary
Apr. 1986 Joined Mitsubishi Corporation
Sep. 2002 President of Nanotech Partners Inc.
May 2003 Served as Director, COO and CFO, and President & CEO of Medical ProteoScope Co., Ltd.
Oct. 2007 Executive Officer of CSK Institute for Sustainability, Ltd.
May 2010 Served as, among others, General Manager of Business Development Division, Executive Officer and COO of Overseas Business Group of Lawson Inc.
Nov. 2012 Served as, among others, consultant and Director of Nitto Boseki Co., Ltd. and Senior Managing Director of Nittobo Medical Co., Ltd.
Dec. 2014 Advisor to the Company
Jun. 2015 Director, CFO and Head of CEO Office of the Company
Jun. 2018 Director of Entrust Inc. (current)
Nov. 2019 President & CEO of the Company
Jan. 2023 Vice Chairman and Director of the Company (current)
Jun. 2023 Auditors to the Company (current)

Takashi Matsuo

Outside Auditors

Career Summary
Apr. 1984 Joined YAMAZEN CORPORATION
Apr. 1998 General Manager of Corporate Planning Department of AUTOBACS SEVEN Co., Ltd.
Jun. 2002 Director and Executive Officer in charge of Corporate Planning, Finance & Accounting, PR and IR and General Manager of Corporate Planning Management Office of AUTOBACS SEVEN Co., Ltd.
Jun. 2004 Director and Officer in charge of Corporate Strategy Promotion and General Manager of Corporate Planning Management Office of AUTOBACS SEVEN Co., Ltd.
Apr. 2006 Director and CSO and Head of Corporate Strategy Promotion of AUTOBACS SEVEN Co., Ltd.
May 2007 Director and CSO, Head of Corporate Strategy Promotion and Co-COO and Head of Overseas Business Strategy Promotion of AUTOBACS SEVEN Co., Ltd.
Apr. 2010 Representative Director and President of TAIYO Co., Ltd.
Apr. 2013 Representative Director and President of AUTOBACS Nankai Ltd.
Apr. 2014 Representative Director and President of AUTOBACS Fukuoka Ltd.
Apr. 2021 Councilor of AUTOBACS Minami-Nihon Sales, Ltd. (current)
Jun. 2023 Auditors to the Company (current)

Seiichiro Wada

Outside Auditors

Career Summary
Apr. 1986 Joined Nomura Securities Co., Ltd.
Jul. 2008 Head of Real Estates Investment Business Department of Nomura Securities Co., Ltd.
Apr. 2013 Head of Overseas Sales Department of Nomura Real Estate Asset Management Co., Ltd.
Oct. 2014 Managing Director of Nomura Real Estate Asset Management Co., Ltd.
Apr. 2015 Executive Managing Director of Nomura Real Estate Asset Management Co., Ltd.
Apr. 2017 Audit and supervisory board member of Nomura Real Estate Asset Management Co., Ltd. (current)
Jun. 2023 Auditors to the Company (current)